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System Biology

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Better System. Better Balance.

Better Health.

Systems biology uses algorithms to measure body system balance in a holistic “real-life” forecast. We measure six Systems key to fertility health.​

The fundamental issue for women with Blood PFPs is improving the health of their blood and energy reserves. Blood tests are a familiar part of the first line of diagnostic tests, and there are narrow ranges for “healthy” blood. Many factors alter blood test results, including age, diet, trauma, hydration and immune challenges (which can change how blood behaves rapidly).

Blood is crucial for health, and the quality and quantity of a woman’s blood naturally makes changes with the menstrual cycle. Energy levels fluctuate for everyone, but Blood PFP women tend to be less energetic than most of their friends and colleagues due to blood issues.

There are close connections between Blood PFP and Energy PFP as blood transports oxygen and nutrients to muscles. The digestive weakness and dietary issues that are common causes of Energy PFP also contribute to people being Blood PFPs, and anaemia creates feelings of tiredness. In many ways, our blood is a significant energy reserve that supports muscle and organ function and is crucial for fertility. There are variations in how Blood PFP can develop, which we’ll call “Constitutional” and “Life” Blood.

“Constitutional Blood”

Our constitutional health is primarily the genetic packages we inherited from our parents, with the genes on our chromosomes determining much about us. One of the things we all have is genetic traits that affect how much blood we make and how it functions.

However, genes aren’t 100% stable, and their behaviour (and structure) changes in response to age, diet and the environment:

Genetic robustness determines our health at birth, how quickly we age, and our changing fertility levels.
Genetic variations affect our blood, including how efficiently it carries oxygen and responds to immune threats and clots.
Our genetics aren’t “set” or constant, and different genes are “expressed” throughout our lives. Aplastic anaemia is an example as it can be purely genetic or triggered by disease or toxins.
Triggers of gene expression include hormones, diet, exercise and chemicals.
Modern living is full of new chemicals, and many are “endocrine-disrupting chemicals” (EDC) that alter hormones and disrupt egg production.

Constitutional forms of anaemia

These are conditions that reduce red blood cell numbers, the amount of haemoglobin in the blood, or haemoglobin’s ability to transport oxygen and waste products.

Name Cause Explanation
Thalassemia Genetic (HBA1 & HBA2) Reduction in haemoglobin production
Acanthocytosis Genetic Abnormal blood cells as a result of an inability to fully digest fats.
Aplastic anaemia Genetic, immune disease or toxins The bone marrow doesn’t create enough blood cells.
Megaloblastic anaemia Genetic DNA synthesis in red blood cells is inhibited.
Sickle cell anaemia

Hereditary elliptocytosis

Genetic Abnormal cell shapes in response to potential local diseases.

“Life Blood”

These are lifestyle choices or events that reduce red blood cell numbers, the haemoglobin in the blood, or haemoglobin’s ability to transport oxygen. We’ve listed the leading causes of non-genetic anaemia, but other triggers, including exposure to severe cold, or menopause, can induce anaemia.

Name Cause Explanation
Iron deficiency anaemia Dietary Low iron levels reduce the production of red blood cells
Protein deficiency anaemia Dietary Low protein in the diet restricts blood cell formation
Scurvy Dietary Low Vitamin C, which is needed to make collagen
Vitamin B12 deficiency anaemia Dietary 1Low B12 reduces the production of red blood cells
Folate deficiency anaemia Dietary Low folate in the diet reduces the production of new blood cells
Post-haemorrhagic anaemia Blood loss Trauma or other cause of bleeding reduces blood cells
Pernicious anaemia Loss of gastric cells The loss of gastric cells reduces the absorption of Vitamin B12
Chronic disease anaemia Inflammation The body converts iron into ferritin in response to inflammation
Drug-induced anaemia Medication (esp. penicillin) High doses of drugs reduce blood cells in the spleen or trigger an autoimmune reduction of blood cells

Diet is a significant factor for abnormal blood values, which offers the possibility of improving blood function by changing diet. Blood loss is another consideration, and as women can have heavy periods, they’re generally affected more than men. However, both sexes can silently lose blood, usually via ulcers in the intestines.

Blood is crucial for our health and wellbeing. It moistens, provides oxygen and nutrients to cells, removes waste products, is vital for immune health and distributes heat around the body. Low blood levels cause:

    1. Tiredness
    2. Weakness
    3. Pale skin
    4. Cold hands
    5. Postural dizziness
    6. Lower immunity
    7. Breathlessness
    8. Anxiety and vulnerability
    9. Insomnia

Blood PFP and Emotional Health

Emotional wellbeing and the state of blood in the body are closely connected:

  • People with anaemia are more likely to experience depression, and the more depressed a person is, the more likely they are to be anaemic
  • Anaemia raises the risk of depression, insomnia and anxiety

Given how crucial blood is for heart health, this isn’t surprising, and lower blood volumes and health increases the chance of feeling vulnerable and getting palpitations. This connection to emotional vulnerability increases the importance of maintaining a healthy autonomic nervous system (ANS) balance.

The ANS is crucial for hormone balance, sexual arousal and fertility levels, and good blood health. A balanced ANS increases oxygen supply to the ovaries and enhances mood and sexual health.

Blood Health and Female Fertility

Healthy blood is essential for immune balance and vitality, and for women, it’s also crucial for developing eggs, follicles, and womb lining. Problems with circulation and blood function reduce female fertility as blood carries oxygen and hormones, and low oxygen levels raise the chances of sub-optimal organ function and cell death. 

Anaemia can play a significant role in female fertility as it disrupts the hypothalamus-pituitary-ovary axis. Low oxygen saturation leads to hypoxia and “oxygen debt”, which puts great pressure on cells, especially when they’re growing and dividing. Expert advice is:

“Any attempts to treat infertility [ ] should be delayed until anaemia is treated.”

Hormonally normal women with iron deficiency anaemia are more likely to have: 

  1. Low haemoglobin levels
  2. Ovulatory infertility
  3. Gallstones

30% of non-pregnant women have anaemia, and anaemic women are up to 60% more likely to have fertility problems due to:

  • Higher egg loss rates
  • Lower egg quality
  • Miscarriage due to low oxygen levels

Thalassemia major is the most common haemoglobin disorder in the world, and those of Mediterranean, Arab or Asian origin are particularly affected. About 1.5% of people worldwide carry the gene, and 40-80% of women with the condition have damage to their pituitary gland that affects menstrual cycles. However, medical advances enable many women (and men) with this condition to conceive.

Not all Blood PFP women have a medical condition, but improving the health of their blood goes a long way to raising their fertility and the chances of conception. The hormone erythropoietin (EPO) from the kidneys stimulates stem cells in the bone marrow to produce red and white blood cells. 

Morefertile and Blood PFP Women

The morefertile member package has PFP extensions with personalised advice on:

  • Diet
  • Lifestyle
  • Coping with stress
  • Appropriate tests and treatments

They also have the most up-to-date research for specific conditions and access to cutting-edge functional medicine tests and personalised herbal combinations. The morefertile approach: 

  • Informs and empowers you with focused changes to raise fertility
  • Uncovers and addresses hidden problems
  • Raises general and fertility health
  • Speeds up natural conception times
  • Improves IVF success rates
  • Increases resilience and lowers stress levels